Q: I would like to discuss DCA treatment as soon as possible. My father has recurring Non-Hodgkin lymphoma - which is being treated with R-CHOP. After treatment, my dad experienced C.Diff and is now in the hospital. There are currently other complications and he has liver cirrhosis. R-CHOP is not the answer. We need to seek alternative solutions. I would like to discuss this with someone. Best, Inessa. A: Hello, Inessa, this is a rather difficult situation. On one hand, Sodium dichloroacetate can indeed be used to treat and control your father’s lymphoma. On the other hand, taking DCA while one has liver cirrhosis and poor liver function at home is unsafe. This is because Sodium dichloroacetate is metabolized in the liver and needs proper liver health to be properly digested. Your best bet would be to take the lowest DCA dose possible (6.25 mg/kg daily) by yourself at home or to take him to a DCA clinic where he could receive DCA intravenously. Intravenous Sodium dichloroacetate causes far less side-effects and is tolerated better than oral DCA. If you want a consultation with one of the best DCA specialists in the world - try reaching out Dr. Akbar Khan at Medicor Cancer. They can do telemedicine appointments or you can visit them in Canada. Regarding DCA and Non-Hodgkin's lymphoma, as you have already noticed - we have a big article on that: DCA and Cancer: Non-Hodgkin's lymphoma cured in 4 months (Case presentation). The main point of the paper is that one can achieve remission and keep cancer-free with the help of DCA. This is a real life example. Please read the article carefully. After you're finished reading it, you can read two studies that discuss this case in more details: 1) Non-Hodgkin's Lymphoma Reversal with Dichloroacetate (Case Report), 2) Complete response with DCA in non-Hodgkin’s lymphoma after disease progression (Case report). Last but not least, the Clostridium difficile infection could have been caused by the chemotherapy he received, antibiotics or compromised immune system. If he has C. difficile, he should be treated in the hospital by his physicians to avoid severe complications. Your doctor will prescribe vancomycin, fidaxomicin and / or metronidazole orally. He should also take as much fluids as possible to avoid shock. A diet that has low fiber and greens is also helpful, he should eat rice, bread, soup, fish or chicken etc. till he recovers.
Q: Cancer took the most part of the liver (3/4), but still not completely gone. We are still going to give DCA as this is our last hope, but we are also going to give some vitamins specifically for the liver. Should we give these vitamins or not? On your website, it seems like it is encouraged to give. Is there any recommended dosage for Silymarin? I found this supplement below in Turkey, they recommend 1 capsule a day, and it has 80% Silymarin, but I couldn't be sure if it is enough in our case. Kurtulus. A: Dear Kurtulus, thank you for reaching us out. Adult dosage in terms of hepatoprotection is 420 mg/day of Silymarin extract (standardized to 70-80% Silymarin). I would advise to take three 140 mg capsules a day. Take one with breakfast, second one with lunch and the last one with dinner. You can also take Essential phospholipids (EPL) to help speed up liver recovery from light or heavy damage. The recommended dosage is 900-1800 mg/day. Take three 300 or 600 mg capsules daily with your meals. These supplements are extremely safe and have virtually no drug interactions. They are also used in a healthcare setting to aid liver recovery. However, you need to take them at least 2-6 months straight for the effect to be evident. You can take Silymarin and Essential phospholipids separately or together for swift and positive response. It‘s up for you to decide.
Q: Taking DCA 2 week on with 1 week off I understand... How long term can a person take the DCA, 6 months, years ? Kreuzman. A: Dear Mr. Kreuzman, thank you for your question. There are no official guidelines on how long DCA can be taken. Regarding safety, there have been documented reports of people taking DCA for more than 4 years (https://www.dcaguide.org/news/dca-and-cancer-melanoma-long-time-remission-and-stabilisation-case-presentation-101258). In some clinical studies, children have taken DCA for even longer periods of time. If someone has stage IV cancer which has spread, then DCA and other regimens should be taken as long as possible to keep cancer stabilized or cured. How long can a person take Sodium dichloroacetate also heavily depends on how well the patient tolerates the DCA protocol, whether there is any preexisting liver failure or previous nerve injury. Diabetes can also cause nerve damage, therefore, preexisting diabetic neuropathy should be treated as much as possible before continuing the Sodium dichloroacetate treatment. Some people take it for years to keep themselves in remission. Our suggestions for longer time periods would be: • Stop taking DCA if you experience side effects. You can resume once they resolve. • Stop taking DCA if you have severe chronic liver failure, acute hepatitis, chemotherapy-associated liver injury. You can resume DCA once the liver is in better function. • Stop taking DCA if you experience abnormal liver enzyme (AST, ALT, GGT) elevation 2.5 times from the upper limit of normal levels. Take 1) silymarin or milk thistle, 2) essential phospholipids. Take a break till the liver enzymes return to normal levels. • Take DCA till you treat cancer or you want to maintain remission. Please don't forget to take the neuroprotective supplements such as Vitamin B1, Alpha-Lipoic acid and, if possible, Acetyl-L-Carnitine.