Q: Dear Sir or Madam, I have a question about DCA, next week I start with immune therapy because I have lung cancer. Is it safe and can I still use DCA? Best regards, Alfredo. A: Dear Alfredo, thank you for your letter. We are getting similar questions often, therefore, we will try to explain DCA and immunotherapy in greater detail. In most cases, using Sodium dichloroacetate with checkpoint inhibitors such as pembrolizumab (Keytruda), atezolizumab (Tecentriq) and other similar drugs is a great option. It does not look that DCA could be unsafe with any type of immunotherapies. (Ref.) Immunotherapy helps the person’s own immune system fight against tumors. This class of medications is especially useful when the cancer develops resistance against conventional chemotherapy treatment. It also allows the immunity to bypass the special proteins that cancer cells develop as “camouflage” to continue growing and expanding. As the cancer progresses, it continues to develop an acidic environment around it. Lactic acid is considered an important factor in driving cell invasion, angiogenesis and immune suppression. Unfortunately, this process disables the immune system from fully engaging in tumor eradication. Furthermore, it diminishes the effectiveness of immunotherapy. The mechanism can be seen in the scheme below. (Ref.) It is proven that DCA successfully inhibits aerobic glycolysis in cancer. This decreases the massive amount of lactate secreted by the tumor cells and prevents acidosis. The surrounding extracellular space remains in normal pH, thus the immune system can recognize and destroy tumors more effectively. Considering everything, if you aim to efficiently treat cancer, Sodium dichloroacetate and immunotherapy can go hand in hand. These are the key points that you should keep in mind when using DCA alongside immunotherapy: • You should be free from peripheral neuropathy caused by previous chemotherapy treatment, • If you develop rare neurological complications from immunotherapy such as Guillan-Barre syndrome, encephalitis or any type of neuropathies, please stop DCA treatment until the side effects resolve, • Avoid using DCA, Vitamin B1 and Alpha-lipoic acid during your stay at the hospital while you’re receiving immunotherapy, you can resume DCA and supplements 2 days after you’re released from the healthcare setting, • If you’re receiving cytotoxic chemotherapy, such as platinum based compounds (cisplatin, carboplatin, oxaliplatin) or taxanes (paclitaxel, docetaxel) – avoid using DCA and Alpha-lipoic acid 3 days before hospitalisation and 7 days after receiving chemotherapy infusions. After that time period, if you haven’t developed chemotherapy induced peripheral neuropathy, you can continue using the DCA protocol as usual. Remember, DCA fights cancer on its own and can be used as monotherapy, but when it is incorporated with immunotherapy, the combination should work even stronger. (Ref.) Hope you find this information useful. Best regards, DCA Guide
Q: Can we use along with Keytruda/Pembrolizumab ? Jon D. A: Hello, Jon. Yes, DCA can be safely used with Keytruda (Pembrolizumab) as no drug-drug interactions are expected. (Ref.) As far as we heard from our own experience, there haven't been any bad interactions between Sodium dichloroacetate and biological therapy. Also, based on research and cancer biology facts, it seems that DCA and immunotherapy can go hand in hand. (Ref.) You can find more details in the previous answer that analyses Sodium dichloroacetate and immunotherapy in-depth. (32)
Q: Good Day, my Aunt has stage 4 colon cancer with metastasis. She is 5'7 and is weighing 140 pounds. Do you recommend starting DCA treatment and if so what dose should she take? Thank you. Isabel. A: Dear Isabel, thank you for your question. DCA therapy can help in almost every case of cancer, with varying degrees of success. The majority of people experience improvement in their symptoms, some have their disease stabilized and live without further cancer progression, and some even achieve remission thus remaining cancer-free. Nevertheless, stage IV colon cancer means that the tumors have spread in the body, this could make the treatment more difficult. Despite that, a clinical case published by Dr. A. Khan displays that DCA can be great for treating advanced colon cancer even when traditional medical treatments fail. You can read the study here: Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy. In the example of this 57-year-old woman, the stage IV colon cancer was stabilized with the help of Sodium dichloroacetate therapy and did not progress. It also did not cause any serious toxicity in the period of 4 years. The female remained highly functional and could continue running her own business, which proves that DCA treatment can be less debilitating than traditional chemotherapy. We could go on and on about the potential benefits of the Sodium dichloroacetate. To answer your question, we would recommend your aunt trying DCA. She can take it as a single treatment or combine it with the traditional chemotherapy (5-fluorouracil, oxaliplatin or irinotecan etc.) or immunotherapy (Avastin/bevacizumab). You can take DCA with Avastin without taking any breaks. However, when you‘re receiving chemotherapy – please make a two day break from DCA and Alpha-lipoic acid before getting chemotherapy and a three day break after receiving chemotherapy. Afterwards you can resume to taking the DCA protocol as usual. For your aunt, weighing 140 lbs, she should begin with 12,5 mg / kg a day. Take it for two weeks then do a one week break. This would mean that she takes one of the following: 1) 800 mg of DCA powder, 2) two 333 mg capsules with breakfast and one 333 mg capsule with dinner, 3) one 500 mg capsule with breakfast and one 500 mg capsule with dinner. If she tolerates DCA without any problems, she can move up to taking 25 mg / kg a day. Take it for two weeks, then take a week off. Repeat the cycles. Take one of the following: 1) 1600 mg of DCA powder, 2) three 333 mg capsules with breakfast and two 333 mg capsules with dinner, 3) two 500 mg capsules with breakfast and one 500 mg capsule with dinner. Don‘t forget to take the advice and supplements we describe here. Don't forget to take Vitamin B1 and Alpha-Lipoic acid with DCA just like we described. From our experience, we can tell that this is the biggest mistake some people tend to make. Here…
Q: Dear DCA guide, I am looking for support with guiding my mother (who is diagnosed with uveal melanoma, stage 3, mets) with start of using DCA. She already started ketogenic diet for some time, but now wants to add DCA with this. However we can't find any specialist/professional in our region. Can you help us out with this? Regards, Cees. A: Dear Cees, we would like to show you a really interesting study about melanoma + DCA Long-term stabilization of metastatic melanoma with sodium dichloroacetate. To make a long story short, a young man used DCA for a handful of years and it stabilized his melanoma, even shrunk the lymph node metastasis. He finally got better and afterwards added immunotherapy to the treatment. This was a great result, since the previous treatments prior to Sodium dichloroacetate had little to no effect. Your mother can definitely take DCA with Ketogenic diet for the treatment of Melanoma. It can stabilize as well as treat this type of skin cancer. Also consider talking with your oncologist, maybe he can add immunotherapy or targeted therapy to the picture for even better results. If you‘re clueless where to start with DCA, you can find a lot of information that you need to know about Sodium dichloroacate for free in our site. Please read it closely. Analysing DCA information is a must. Also, we advise you following your doctors advise, especially if he's offering biological therapy for melanoma. You can use the Ketogenic diet and DCA with the conventional treatment options. Regarding your question about specialists and medical professionals in Europe. There are many specialists and naturopathic clinics in Germany who prescribe Sodium dichloroacetate for cancer. However, we have no contact with them. You will need to find them yourself. If you have the funds and the time, you can try reaching out Dr. Akbar Khan in Canada. He's one of the best DCA oncologists in the world. You can find his site here at Medicor Cancer.