Q: I have an aunt with breast cancer IV. Can you inform me about the right products please? Daniel A: Dear Daniel, thank you for your email. We understand that this is a really hard time for you and your family. She should continue getting regular health exams by her oncologist as well as other doctors that are following her current situation. If your aunt is receiving any kind of therapy and it is not too heavy on her well-being, please continue doing that. The best results are achieved when you combine traditional and alternative medicine together. To answer your question, there are a number of available options for people with metastatic breast cancer. First of all, if she doesn't have peripheral neuropathy or liver function impairment, she can consider taking DCA (sodium dichloroacetate). You can find all the information you need on this page: https://www.dcaguide.org/dca-information. You can also choose where you get your product from all the suppliers that we reviewed: https://www.dcaguide.org/suppliers. You will definitely find something that can suit your needs. DCA needs at least 4-6 weeks to start working. Secondly, you could also use fenbendazole as a part of your anti-cancer protocol. There have been studies suggesting that DCA becomes even more potent when used in combination with fenbendazole: Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways. Fenbendazole also works against breast and a big variety of other cancers by itself. You can find more about fenbendazole on this site: https://www.fenbendazole.org/. Recently, we've heard reports that this medication can help people with breast cancer, stabilizing the disease or shrinking the breast tumors. Just please make sure that the relative doesn't have any significant liver problems such as cirrhosis or jaundice prior to starting fenbendazole. As with DCA, you also need some additional time for fenbendazole to start working. It is usually about 6-8 weeks. Last but not least, the third option that is quite similar to fenbendazole is niclosamide. It's a new substance that the complementary cancer treatment community has been following closely. However, it's still relatively young and needs more information on the exact mechanisms on tumors. Nevertheless, please give a look at https://www.niclosamide.org/ and research any available data on its potential against breast cancer. It should be great when used in combinations with other anti-cancer regimens. If she is currently receiving no angiogenesis inhibitors such as Bevacizumab (Avastin), your aunt can try Ammonium tetrathiomolybdate (TM). It is an anti-cooper agent that promotes survival in metastatic breast cancer. This molecule can be combined with DCA for better results. It should not be combined with chemotherapy. They had positive results in breast cancer patients in this clinical trial: Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases. She should take 40 mg of TM three times per day with meals for about a week. Then…
Q: Hello. Can I take DCA while getting chemotherapy? I get 140mg of Abraxane per week for breast cancer. Maricel A: Dear Maricel, Thank you for your question. Yes, you can try taking Abraxane or Paclitaxel with DCA on the following conditions: • You currently do not suffer from pre-existing neuropathy, especially the one that was caused by previous chemotherapy, • You take a 3 day break from DCA and Alpha-lipoic acid before Abraxane or Paclitaxel injection, • You should resume DCA and Alpha-lipoic acid not sooner than 4 days after your last chemotherapy infusion, • You should resume your daily Vitamin B supplementation as soon as you’re released from the healthcare setting, There are studies, which prove that Sodium dichloroacetate can reverse the mitochondrial damage as well as dysfunction in Paclitaxel treated cancer cells. This reverses Abraxane/Paclitaxel drug resistance and makes the chemotherapy work more efficiently. On top of that, DCA itself causes apoptosis (natural cell death) in cancer, therefore, you receive a combined effect. You can see a comparison made by researchers that observed how well 1) Paclitaxel, 2) DCA and 3) Paclitaxel + DCA work on mice tumors below. (In vivo growth of tumors in mice treated with DCA alone or in combination with paclitaxel.) You can also find the study on DCA + Paclitaxel in the following link: Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation. Hope you find this information useful, DCA Guide
Q: My sister has advanced hormone receptive breast cancer with extensive liver mets. We’d like to try DCA, my only concern is as her liver isn’t in a great way is it safe to take? My worry is liver failure. Unfortunately, we can’t get it via IV in the UK. I’d be greateful for any information. Kind regards, Reena T. A: Hello, Reena! Is your sister on Tamoxifen? (If yes, read this article - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312350/. Tamoxifen + DCA can have a synergistic effect) From our narrow knowledge, we haven't encountered anyone who took DCA and experienced liver problems. However, I would approach this treatment option with relative caution and maybe try lower than medium doses due to existing liver damage. There have been no deaths related to DCA usage and you can find all of the side effects in this article: https://www.dcaguide.org/dca-safety-and-side-effects.This is what we've the article mentions regarding DCA and liver function: ▪ Mild liver enzyme (AST, ALT, GGT) elevation, without symptoms. A majority of medications can cause mild liver enzyme changes in the blood. DCA can cause minimal liver AST,ALT, GGT elevations (about 50 – 60 U/l) for 1 % of the patients. These little alterations should not cause any worries. A more acute and bigger liver enzyme increase can be caused by antibiotics, Tyenol/Paracetamol (acetaminophen), certain types of medicinal herbs and birth control pills. (Ref.) ▪ DCA and the liver. In case of liver failure and severe jaundice don’t use high doses of DCA, because Sodium dichloroacetate is metabolised in the liver. In situations like these, DCA should be administered intravenously and not through the mouth. If the patient experiences AST and ALT or bilirubin elevation by 150% from the upper reference norm, a pause should be made (Ref.)" If I was in your situation, I would check her liver function with liver enzyme blood test. I wouldn't take DCA if AST or ALT were higher than 100 U/l. Elevated Bilirubin can also be a red flag in this situation. All in all, she could use the oral form DCA orally, just in lower quantities, such as 10 - 20 mg/kg DCA daily. I/V DCA injections are difficult to find in the UK and are mostly given in Canada and Germany. We hope we shed some light on your question.
Q: Hello, my dear wife has been struggling with breast cancer and this site has been a great ray of hope. She has recently been put on a drug called Kisqali (ribociclib). Does anyone know if it is compatible with DCA? Or even complimentary? Do you know of any clinics/practices in Australia competent in administering this drug? I look forward very much to hearing from you. Richard. A: Hello, Richard. Unfortunately, Ribociclib (Kisqali) is quite a new therapy against breast cancer and we have found no studies, which discuss of combining it with DCA. However, we've reviewed the pharmacodynamics and pharmacokinetics of Ribociclib and it doesn't look like it should interact badly with Sodium dichloroacetate. In fact, as mentioned before, we have no bad experiences of combining DCA with targeted therapies. Please read carefully our work at DCA Information and learn all you need before administering DCA to your wife. Everything should be fine. Just don't overdose the DCA and remember that the protective supplements that we recommend with the DCA protocol are obligatory. DCA + Kisqali shouldn't cause any problems when used together. In fact, they could both provide benefits. Another therapy for breast cancer, Tamoxifen, has a synergistic effect with DCA. If you want real professional help, please contact Dr. Akbar Khan. He has a cancer center in Canada. He's one of the most famous oncologists who uses DCA with other conventional cancer treatments. We doubt that there is someone better in this field than him.