DCA papers and clinical trials

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For almost a decade there has been a growing interest in Dicholoroacetates potential to successfully get rid of cancer while causing minimal harm to healthy organs. DCA is a relatively cheap substance which cannot be patented by the pharmaceutical industry, thus it could not generate profit for private drug companies. Right now, because of this reason, Dichloroacetate isn’t receiving enough funding and attention which it deserves.

Despite that, there are plenty of ongoing and completed studies which examine the facts of DCA appliance for therapy. This site will present a handful of completed scientific investigations and will constantly update you with the most recent publications related to the subject.

Below you can find full research reports of Sodium Dichoroacetate (DCA) as an anti-cancer agent.

• A Novel Form of Dichloroacetate Therapy for Patients With Advanced Cancer: A Report of 3 Cases
• Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer
• Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines
• Anticancer drugs that target metabolism: is dichloroacetate the new paradigm?
• Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition
• Case Report of Long Term Complete Remission of Metastatic Renal Squamous Cell Carcinoma after Palliative Radiotherapy and Adjuvant Dichloroacetate
• Case Report: Sodium dichloroacetate (DCA) inhibition of the “Warburg Effect” in a human cancer patient: complete response in non-Hodgkin’s lymphoma after disease progression with rituximab-CHOP
• Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report
• Combination of Sulindac and Dichloroacetate Kills Cancer Cells via Oxidative Damage
• Cotreatment with dichloroacetate and omeprazole exhibits a synergistic antiproliferative effect on malignant tumors
• DCA increases the antitumor effects of capecitabine in a mouse B16 melanoma allograft and a human non‑small cell lung cancer A549 xenograft
• Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications
• Dichloroacetate (DCA) Sensitizes BothWild-Type and Over Expressing Bcl-2Prostate Cancer Cells InVitroto Radiation
• Dichloroacetate Affects Mitochondrial Function and Stemness-Associated Properties in Pancreatic Cancer Cell Lines
• Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells
• Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells
• Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via inhibiting autophagy in non-small-cell lung cancer
• Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells
• Dichloroacetate Induces Apoptosis in Endometrial Cancer Cells
• Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells
• Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: a novel evidence-based medical hypothesis
• Dichloroacetate potentiates tamoxifen-induced cell death in breast cancer cells via downregulation of the epidermal growth factor receptor
• Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells
• Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway
• Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts
• EFFECT OF DICHLOROACETATE ON LEWIS LUNG CARCINOMA GROWTH AND METASTASIS
• EFFECTIVENESS OF SODIUM DICHLOROACETATE AGAINST GLIOMA С6 DEPENDS ON ADMINISTRATION SCHEDULE AND DOSAGE
• In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines
• In Vivo Evaluation of the Antitumor and Immunogenic Properties of Silver and Sodium Dichloroacetate Combination against Melanoma
• Inhibition of retinoic acid receptor β signaling confers glycolytic dependence and sensitization to dichloroacetate in melanoma cells
• Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation
• Long-term stabilization of metastatic melanoma with sodium dichloroacetate
• Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy (Case report)
• Medullary thyroid carcinoma relapse reversed with dichloroacetate: A case report
• Metabolic Modulation of Glioblastoma with Dichloroacetate
• METFORMIN ENHANCES ANTITUMOR ACTION OF SODIUM DICHLOROACETATE AGAINST GLIOMA C6
• Mitochondrial induction as a potential radio-sensitizer in lung cancer cells – a short report
• Non-Hodgkin’s Lymphoma Reversal with Dichloroacetate
• Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy
• Pharmacogenetic considerations with dichloroacetate dosing
• Prolonged Survival After Dichloroacetate Treatment of Non-Small-Cell Lung Carcinoma-Related Leptomeningeal Carcinomatosis
• Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo
• Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate
• Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy
• Sensitization of metformin-cytotoxicity by dichloroacetate via 4 reprogramming glucose metabolism in cancer cells
• Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer
• Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM)
• Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression
• Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells
• The effect of dichloroacetate in canine prostate adenocarcinomas and transitional cell carcinomas in vitro
• Therapeutic Modulation of Cancer Metabolism with Dichloroacetate and Metformin