DCA in cancer therapy: introduction and general points


Sodium dichloroacetate, or DCA is a well known orphan drug that has been used for decades before discovering that it could be repurposed as an anti-tumor medication.

It has been used as the only available reactivator of mitochondria for children with genetic diseases, which lead to congenital lactic acidosis and eventually death. Now it is on the brink of becoming the first FDA-approved drug for treating this type of diseases. [ Ref. ]

In the last decade, it has been discovered that it could help treat a large variety of human tumors, including brain, lung, colon, prostate, breast, bladder and many other cancers. It is believed that it does so by leading cancer cells selectively to apoptosis (without harming normal cells) and blocking the sugar mechanism. [ Ref. ]

The growing interest and arising questions by people who are unfamiliar with this molecule lead us to starting a short series of infographics that will help you better understand the main point about using sodium dichloroacetate for treating and controlling malignant diseases.

This time we will begin with a brief overview on how DCA works, what type of tumors does it target and how it can be used alongside conventional therapy.