DCA and 5-Fluorouracil combination - twice as good results on Colorectal Cancer

Published: 1 December 2016

CRC without doubt is one of the most common cancers in the world. Luckily, if caught early - it is quite curable by surgery. Later stages of Colorectal Cancer become more dependent on chemotherapy treatment. Usually chemo drugs are not used alone, it is preferred to combine two or more substances simultaneously. This way the treatment is more effective and the patient experiences less toxicity when dealing with cancer.

As far as we know, DCA is able to provide an outstanding effect against certain malignancies while causing little to none adverse reactions. It is not surprising that it can be used at the same time with other antitumor prescriptions to provide a better outcome for someone, who is suffering from cancer. Apparently, a team of researchers felt enthusiastic about using DCA with the most favored medication and decided to give it a shot against Colorectal Cancer. These were the news.

It appears that the combination of Dichloroacetate and 5-Fluorouracil has an enhanced antitumor effect. The duet has the potential to eliminate larger masses of Colorectal Cancer cells when used simultaneously. It is also possible that this new way of treatment can be more health-preserving and less toxic because of the lower doses required to achieve desirable therapeutic effects.

First of all, let's briefly remember some facts about 5-Fluorouracil. For several decades, it has been a classical choice for treating gastrointestinal tumors (including Colorectal Cancer) and other malignancies.  Anyone who is diagnosed with progressed CRC will most likely receive 5-FU as chemotherapy. However, the problem is that it seems to be quite difficult to choose the adequate dosing and the right scheduling to achieve maximum results while avoiding unpleasant side effects. 5-Fluorouracil is known to be one of the minority of drugs which have dramatic toxicity shifts depending on the quantity. Sadly, the drug may cause major toxicity to the bone marrow and provoke myelosuppression. Other, minor side effects include classical adverse reactions which are often experienced with chemotherapy (etc. mucositis or nausea and so forth). Naturally, all of this motivates us to find out ways for avoiding such grim outcomes while preserving the healing effect. Currently combination therapy with 5-FU is used widely in hoping of finding relatively safe and effective regimens.

By this time, most of us probably have heard that with the help of dichloroacetate we can attempt  to restore mitochondrial function, reverse the Warburg effect and promote apoptosis in malignant cancer cells. The substance is not only inexpensive, it is selective, does not harm healthy organs and proves to be quite effective. Taking all of this into consideration, DCA appears to be a fine candidate which could be advantageous for the classical CRC chemotherapy agent.

With this in mind, recently a handful of scientists from the Third Military Medical university decided to examine the possible outcome of DCA and 5-Fluorouracil combination on Colorectal Cancer. After series of experiments they presented their discoveries. The results were impressive. It was proven that dichloroacetate not only causes apoptosis in CRC cells, it also enhances the clinical activity of 5-Fluorouracil serving as a great, potential synergistic component in combination therapy.

On the whole, a couple of things are quite obvious - it is difficult to accurately predict how new ways of antitumor treatment could affect patients suffering from cancer. As far as it goes, we know that DCA does not provoke any significant health issues. Bearing this in mind, it is safe to claim that when dealing with CRC, dichloroacetate could only provide benefits. It's great to know that the results of DCA + 5-FU treatment in vitro appear to show splendid outcome on CRC cultures. However, we must be aware that the original 5-Fluorouracil treatment should not be replaced, it should be supported with the synergistic effects of dichloroacetate. Finally, who knows? Maybe this will become the more safe, the more effective  way to approach Colorectal Cancer?

If you're interested in the study, please find out more below:
Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer